Novozyme 435 Asymmetric Hydrolysis of Enol Ester with Series Acid Moiety
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چکیده
منابع مشابه
[Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety].
Prodrug is a useful approach for improving the bioavailability of therapeutic agents through increased passive transport. Carboxylesterases (CESs, EC.3.1.1.1.) that show ubiquitous expression profiles play an important role in the biotransformation of ester-containing prodrugs into their therapeutically active forms in the body. High levels of CESs are found in the liver, small intestine and lu...
متن کاملAsymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst.
[reaction: see text] The Rh-TangPhos catalyst has been used for asymmetric hydrogenation of itaconic acid and enol acetate derivatives. A variety of chiral 2-substituted succinic acids and chiral acetates have been obtained in excellent ee values (up to 99% ee).
متن کاملTriglyceride and cholesteryl ester hydrolysis
Cultured rabbit aortic smooth muscle cells were converted to foam cells by exposure to sonicated lipid droplets of defined composition using an inverted culture technique. Uptake of the lipid droplets by the cells was shown to be dependent on the time of exposure to the droplets and on the mass of droplets presented to the cells. A comparison of the hydrolysis of triolein and cholesteryl oleate...
متن کاملThe free energy of thiol ester hydrolysis.
Thiol esters, such as aeetyl coenzyme A, the principal biological carrier of activated acetyl groups, have generally been supposed to be “energy-rich” compounds; i.e. to have a free energy of hydrolysis at pH 7.0 in the range of -7000 to -14,000 calories per mole. The reported numerical values for the free energy of thiol ester hydrolysis have varied over a wide range (for recent estimates see ...
متن کاملThe pH-dependence of enzymic ester hydrolysis.
The esterases of animal tissues have generally been characterized by their substrate specificity and by their behaviour towards various inhibitors. The irreversible inhibition by organic phosphates, which is due to phosphorylation of the active group (Burgen, 1949; Wilson & Bergmann, 1950a; Aldridge, 1953d), is a common property of most esterases, an interesting exception being the Aesterase of...
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2014
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2014.16200